H5N1 virus acquires human-to-human easy transmission capability by June 1st, 2027
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2026
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This market predicts whether the H5N1 avian influenza virus will mutate to enable efficient human-to-human transmission by June 1st, 2027. Resolution will be based on official reports from the World Health Organization (WHO). WHO Avian Influenza Updates

  • Update 2025-05-24 (PST) (AI summary of creator comment): The creator clarified the definition of 'easy' or 'efficient' transmission. The virus acquiring such capability will be characterized by:

    • Transmission in a way similar to SARS-CoV-2.

    • Transmission modes potentially including airborne, respiratory droplets, and/or aerosols.

    • Possible spread through surface fomites (potentially more efficiently than SARS-CoV-2).

    • The R0 (basic reproduction number) must be > 1.

    • This determination of 'easy' or 'efficient' transmission, incorporating these characteristics, must be made by a health entity outside the US, such as WHO.

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Can you define ‘easy’ or ‘efficient‘ transmission?

@MachiNi The R0 must be more than one (each new case spreading the virus to more than 1 other person.)

The virus will transmit in a way similar to SARS-COV-2 and/or through surface fomites. This might be officially defined as through airborne, respiratory droplets, and/or aerosols. It may spread through fomites on surfaces much more efficiently than SARS-COV-2 does.

There may be the kind of initial confusion that there was in 2020 over the exact definition of 'airborne" and "aerosol."

This must be a definition/decision made by a health entity outside the US, such as WHO. The CDC/NIH may or may not make this decision.

The cases will begin to double over a shorter and shorter period of days. However, this might not be officially confirmed until after June 1, 2027, so I am not including it in the official criteria.

All of this criteria may or may not be retrospectively defined as having actually begun long before the 2 year mark.

@CatieD Thanks!

I've been studying this issue intensively for over a year, and there is very little question in my mind that the H5N1 virus will mutate to spread effectively between humans within the next 2 years. I can provide cites if anyone wants to see them.

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