
The development of a self-replicating assembler with nanometer-scale functional components has significant implications for various fields, including manufacturing, medicine, environmental remediation, and computing.
Despite the potential benefits, developing a self-replicating assembler with nanometer-scale functional components presents numerous scientific and technical challenges. Some of these challenges include precise control of atomic and molecular assembly, error-correction mechanisms, energy and resource management, and integration of functional components.
Resolution criteria:
This question will resolve to "YES" if, before January 1st 2040, an artificial self-replicating assembler is publicly and credibly documented to have:
- Been composed of functional components, where over 90% of the components have dimensions between 1 and 100 nanometers. These components can be analogous to the molecular machines, enzymes, or structural elements found in biological systems, but need not be identical to their natural counterparts. 
- Successfully constructed a copy of itself with a replication accuracy of at least 99% within a 72-hour period, without human intervention beyond the initial setup. A replication accuracy of 99% means that, on average, no more than 1% of the functional components, atoms, or molecular connections in the copy differ from those in the original assembler. 
- Demonstrated a complexity threshold by incorporating a minimum of 1,000 non-hydrogen atoms in its structure, with at least 10 distinct types of components or functional groups in its design. 
A functional component is defined as a distinct part of the assembler that performs a specific function, such as energy production, movement, or molecular synthesis.
A successful demonstration must be accompanied by:
- A publicly accessible report or documentation describing the self-replicating assembler, its structure, components, and replication process. 
- Independent validation of the results by at least two separate entities with expertise in nanotechnology, molecular manufacturing, or related fields. These entities can be research groups, institutions, or companies. 
- Video or photographic evidence of the self-replicating assembler and its replication process, as well as any available analytical data supporting the claims. 
I will use my discretion when resolving this question, possibly in consultation with experts.
By what criteria do "current" RNA approaches fail to resolve this market? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943892/